Mortality in sepsis increases with nearly 8% for every hour that treatment is delayed 1 and is the result of a cascade of events, starting with an infection, triggering an overwhelming and life-threatening response in the immune system that eventually may progress to septic shock and result in patient death. Early start of treatment with Alteco LPS Adsorber aims to reverse the sepsis process before septic shock occurs, by taking endotoxin out of the picture. The purpose of removing endotoxin is to decrease the inflammatory response in the immune system to regain control over the systemic failure and stabilize the patient in the acute situation, just before septic shock sets in.

By removing endotoxin from the bloodstream during extracorporeal treatment in hemoperfusion mode, Alteco LPS Adsorber can turn the course of sepsis and stabilize the patient’s hemodynamic parameters in 2 hours. 2 Turning the course of sepsis with Alteco LPS Adsorber may potentially avoid further damage to the kidneys and the need for acute CRRT treatment – sepsis is the leading cause of AKI (acute kidney injury) in ICU – 45 to 70% of all AKI is associated with sepsis. 3

An addition to traditional medical treatment

Example of how sepsis should be treated from international guidelines:

• Intravenous antibiotics
• Oxygen
• Fluids
• Vasopressor support to stimulate the heart and maintain adequate blood pressure

When traditional medical treatment is not sufficient to stabilize the patient, the Alteco LPS Adsorber is an additional therapy to be used – safe, specific and effective in removing endotoxin.

When to start treatment

When should extracorporeal treatment with the Alteco LPS Adsorber be initiated to have the intended effect? Treatment with Alteco LPS Adsorber shall be started as soon as endotoxemia and/or sepsis/septic shock caused by a gram-negative bacterial infection is suspected or verified.

Start treatment with the Alteco LPS Adsorber when the following clinical parameters are met:

• Urine production is decreasing (acute kidney failure approaching)
Mean arterial pressure (MAP) ~ 65 mmHg
>2 hours of vasopressor support and patient still unstable

Treatment duration

The recommended treatment time with Alteco LPS Adsorber is two hours and normally only one treatment is needed. However, the product can be used for up to 6 hours and treatment can be repeated if needed.

Take endotoxin out of the picture

View our product animation to learn more about endotoxin removal and the Alteco LPS Adsorber.

Rinsing and priming

Learn more about rinsing and priming of the Alteco LPS Adsorber.