When should extracorporeal treatment with the Alteco LPS Adsorber be initiated to have the intended effect? Treatment with Alteco LPS Adsorber shall be started as soon as endotoxemia and/or sepsis/septic shock caused by a gram-negative bacterial infection is suspected or verified.

When to start treatment

Start treatment with the Alteco LPS Adsorber when the following clinical parameters are met:

• Urine production is decreasing (acute kidney failure approaching)
Mean arterial pressure (MAP) ~ 65 mmHg
>2 hours of vasopressor support and patient still unstable

Treatment duration

The recommended treatment time with Alteco LPS Adsorber is two hours and normally only one treatment is needed. However, the product can be used for up to 6 hours and treatment can be repeated if needed.

Take endotoxin out of the picture!

Why is it important to treat patients early?

Mortality from sepsis increases with nearly 8% for every hour that treatment is delayed. In addition, sepsis is the leading cause of AKI (acute kidney injury) in ICU – 45 to 70% of all AKI is associated with sepsis. 2

By removing endotoxin from the bloodstream during extracorporeal treatment, Alteco LPS Adsorber can turn the course of sepsis and stabilize the patient’s hemodynamic parameters in 2 hours. 3 Use Alteco LPS Adsorber early to avoid cytokine storms and organ failure. Early start of treatment with Alteco LPS Adsorber aims to reverse the sepsis process before septic shock occurs. Turning the course of sepsis with Alteco LPS Adsorber may potentially avoid further damage to the kidneys and the need for acute CRRT treatment.

An addition to traditional medical treatment

Example of how sepsis should be treated from international guidelines:

• Intravenous antibiotics
• Oxygen
• Fluids
• Vasopressor support to stimulate the heart and maintain adequate blood pressure

When traditional medical treatment is not sufficient to stabilize the patient, the Alteco LPS Adsorber is an additional therapy to be used – safe, specific and effective in removing endotoxin.