Case stories and scientific reports
Endotoxin removal in septic E. Coli bacteremia during continuous veno-venous hemodiafiltration therapy
This clinical report of treatment with Alteco LPS Adsorber in endotoxemic septic shock from pyelonephritis, caused by the gram-negative bacteria E. Coli, shows that the treatment was safe and hemodynamic and respiratory variables improved.
Endotoxin removal therapy stabilizes critical patient with ARDS, multiple infections and septic shock
A 2-hour session of hemoperfusion with Alteco LPS Adsorber column (Alteco Medical AB, Lund, Sweden) resulted in significant decrease in endotoxin activity to 0,39 EAU. 3 hours after endotoxin adsorption treatment vasopressors were discontinued and the patient’s circulation was stable.
Effects of early use of Alteco LPS Adsorber in Acute Aortic Dissection Type A: Preliminary results
We found that early use of Alteco LPS Adsorber during CPB is safe, without lower platelet count or bleeding. Alteco LPS Adsorber reduces the levels of endotoxin resulting in peripheral lactate levels reduction and improvement of tissue perfusion.
Wroclaw, Poland: Endotoxin elimination in patients with septic shock
This study provides strong arguments for using the Alteco LPS Adsorber on patient with septic shock and endotoxemia. Reduced endotoxin activity was seen in the treatment group and a simultaneous decrease in SOFA score, vasopressor requirement as well as decreased serum lactate level.
Oulu University Hospital, Finland: A new endotoxin adsorber in septic shock
Two-hour hemoperfusion with Alteco LPS Adsorber was initiated in patients with septic shock and endotoxemia. Controls were matched for age, focus and severity of illness. Alteco LPS Adsorber treatment was associated with a decrease in noradrenaline dose, decrease in SOFA scores and LPS concentration
Studies and references
Clinical effects of adsorption of lipopolysaccharide in the treatment of Gram-negative severe sepsis
A statistically significant improvement in hemodynamics, oxygenation, and reduced markers of endotoxemia in group therapy with Alteco LPS Adsorber compared with traditional therapy. These effects were attributed with the removal of endotoxin from the systemic circulation. Only in one case using hemofiltration for acute renal failure in the study group (in the reference group in all patients), 28-day mortality was 16.7% and 66.7% respectively. Negative effects were negligible.
