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Alteco LPS Adsorber
Applications
Treatment
- Treatment start
- Treatment modes
Documentation
Further reading
News & events
The company
- About us
- Board
- Team
- Quality
- Investor relations
- Career
Contact

Further reading

Sepsis-Associated Acute Kidney Injury

Sepsis is the most common cause of Acute Kidney Injury (AKI), a life-threatening complication characterized by rapid deterioration in renal function.

Minimizing the release of proinflammatory and toxic bacterial products within the host: A promising approach to improve outcome in life-threatening infections

LPS (endotoxin) induces the release of a broad spectrum of inflammatory cytokines from human peripheral mononuclear blood cells.

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Endotoxin (LPS) plays a part in COVID-19 hyperinflammation.

Serum lipopolysaccharides predict advanced liver disease in the general population

Endotoxin is associated with hospitalization, cancer or death related to liver disease in the general population.

COVID-19 is adding to already burgeoning rates of sepsis, say experts

Single-cell RNA sequencing reveals the sustained immune cell dysfunction in the pathogenesis of sepsis secondary to bacterial pneumonia

Pneumonia is one of the most common causes of sepsis and gram-negative bacteria accounted for 62% in patients with severe sepsis.

Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients

Study finds that bacterial superinfections in critically ill COVID-19 patients are common and “mostly caused by Gram-negative bacteria”, including MDR (multidrug resistant) bacteria.

SARS-CoV-2-Immune-Microbiome Interaction: Lessons from Respiratory Viral Infections

Observations in COVID-19 similar to the immune response in sepsis: bacterial endotoxin mediates proinflammatory signaling, activates the innate immune system through and “leads to overproduction of pro-inflammatory cytokines”.

Possible Cause of Inflammatory Storm and Septic Shock in Patients Diagnosed with (COVID-19)

In the absence of a bacterial infection, antibiotic treatment can cause release of endotoxin, triggering endotoxemia and over-production of pro-inflammatory cytokines - an antibiotic-induced inflammatory storm.

Preexisting and inducible endotoxemia as crucial contributors to the severity of COVID-19 outcomes

Binding and clearing endotoxins from circulation could be an appropriate intervention in the fight against COVID-19. 90% of patients with severe pulmonary forms of COVID-19 had increased endotoxin levels. Comorbidities of COVID-19 are connected via viral–bacterial interactions, initiated by translocation of bacterial products such as endotoxin from the gut into circulation. Increased levels of endotoxin are found in diabetes, obesity, cardiovascular diseases, older individuals but are lower in women.

Elevated levels of endotoxin, oxygen-derived free radicals, and cytokines during extracorporeal membrane oxygenation

ECMO is associated with an endotoxin-related, generalized inflammatory state. "The pulmonary, renal, and cardiac dysfunctions documented with prolonged bypass can all be related to a classic sepsis syndrome."

Sepsis-associated acute kidney injury: is COVID-19 different?

“Overall AKI occurs in about 25-25% of patients admitted to hospital with COVID-19, nearly twice that if admitted to the ICU.”

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