Skip to content

Subscribe

Blood purification
- Endotoxin removal
- Take endotoxin out of the picture!
Applications
Treatment
Knowledge
News & events
Company
- About us
- Board
- Team
- Quality
- Investor relations
- Career
Contact
Downloads

Blood purification
- Endotoxin removal
- Take endotoxin out of the picture!
Applications
Treatment
Knowledge
News & events
Company
- About us
- Board
- Team
- Quality
- Investor relations
- Career
Contact
Downloads

subscribe

Further reading

The Gut Microbiome as a Biomarker of Differential Susceptibility to SARS-CoV-2

The vicious cycle: SARS-CoV-2 spike protein binds to lipopolysaccharide (LPS) -> boosting pro-inflammatory activity -> cytokine storm -> intestinal damage -> impaired barrier function -> translocation of gram-negative bacteria, more endotoxin in the blood stream -> escalating inflammation.

Microbiome in Sepsis and COVID-19

The exaggerated immune response in COVID-19 causes bacterial translocation, releasing endotoxin into the bloodstream and boosting pro-inflammatory activity. This “leaky gut” – reduction in intestinal barrier integrity – is a high-risk factor for sepsis.

Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity

…“it is very likely that gut microbiome dysbiosis and endotoxemia represent the additional pathophysiological explanation for increased COVID-19 severity in obesity”

Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients

In COVID-19 non-survivors, LPS levels are higher at admission and increase in disease progression, which may be associated with death.

Targeting the gut microbiota in COVID-19: hype or hope?

“With disrupted gut barrier, bacteria and endotoxins (e.g. lipopolysaccharides) can enter the systemic circulation and contribute to the exaggerated production of cytokines and eventually trigger endotoxemia and inflammation.”

Another reason to get vaccinated: It prevents sepsis, the condition that makes COVID-19 deadly

“Everyone with severe COVID-19 has sepsis,” said Ian Barbash, a pulmonary and critical care specialist at the University of Pittsburgh Medical Center.”

Bacterial and fungal ventilator associated pneumonia in critically ill COVID-19 patients during the second wave

Ventilator Associated Pneumonia (VAP) is a common and serious complication in COVID-19 patients in the ICU. This study shows antibiotic-resistant gram-negative bacteria is frequently observed.

Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic?

“Patients critically ill with COVID-19 satisfy the diagnostic criteria for sepsis and exhibit a phenotype and pathology with both similarities and differences to that of sepsis caused by other pathogens.”

Acute kidney injury in severe COVID-19 has similarities to sepsis-associated kidney injury- a multi-Omics study

Did you know that AKI in severe COVID-19 and sepsis-associated AKI have similarities?

The Health Burden of Sepsis After Hospitalization
Did you know that sepsis patients can suffer long-term consequences?

Global report on the epidemiology and burden of sepsis

WHO highlights the global public health impact of sepsis.

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

Details on how LPS promotes pro-inflammatory signaling in the immune response.

1 2 3 4 5 6 7

Alteco Medical AB • Höstbruksvägen 8 • SE-226 60 Lund • Sweden

T +46 46 32 86 00 • info@altecomed.com

SUBSCRIBE

© 2021 Alteco Medical AB

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish.
Accept Privacy policy Cookie settings

Privacy & Cookies Policy

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.

Necessary

Always Enabled

Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.

Non-necessary

Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.

SAVE & ACCEPT

Your name*

Your e-mail*