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Alteco Medical AB
Höstbruksvägen 8
SE-226 60 Lund
Sweden

+46 46 32 86 00
info@altecomed.com

Science database

Updated estimates of sepsis hospitalizations at United States academic medical centers

Sepsis occurring after admission has the lowest occurrence, but the poorest outcomes.

Endotoxemic Shock: A Molecular Phenotype in Sepsis

Could establishing the molecular pathogeneses of sepsis subtypes lead to breakthrough individualized treatments?

Patient, Public, and Healthcare Professionals’ Sepsis Awareness, Knowledge, and Information Seeking Behaviors: A Scoping Review

Sepsis is a preventable cause of death but the knowledge varies globally among patients, the public and healthcare professionals. In this survey, 92% of the public in Sweden could correctly identify the definition of sepsis.

Pcv-aCO2 and procalcitonin levels for the early diagnosis of bloodstream infections caused by gram-negative bacteria

Carbon dioxide difference and procalcitonin showed to have high diagnostic value in early identification of blood stream infections caused by gram-negative bacteria.

Burden of Sepsis in India

Insights into the burden of sepsis in India - in patients with sepsis, bacterial infections were most common (77.9%) with the majority being gram-negative bacteria.

Sepsis Pathogen Identification

What technologies are available for sepsis diagnosis and pathogen identification?

…”gram-negative bacteria produce lipopolysaccharides as endotoxins, which activate toll-like receptors on macrophages and other cells, eliciting the release of pro-inflammatory cytokines and chemokines. Constant stimulation of toll-like receptors leads to damage of vascular endothelial cells and causes blood-clotting abnormalities, eventually resulting in tissue injury, multiple organ dysfunction, and death.”

Formulation and screening of synthetic lipoproteins for binding and inhibition of endotoxin

Did you know that lipopolysaccharide (LPS) is the main molecular cause of sepsis?

Minimizing the release of proinflammatory and toxic bacterial products within the host: A promising approach to improve outcome in life-threatening infections

LPS (endotoxin) induces the release of a broad spectrum of inflammatory cytokines from human peripheral mononuclear blood cells.

Roles of the gut microbiota in severe SARS-CoV-2 infection

What role does LPS play in the gut-lung axis dysbiosis in COVID-19 patients? …”the direct invasion of the intestine by SARS-CoV-2 leads to increased intestinal permeability, allowing LPS produced by harmful bacteria to invade the body and stimulate the production of certain cytokines”…

Current status of bacterial translocation as a cause of surgical sepsis

Did you know that the gut is a source of endotoxin, and translocation of bacteria is associated with an increased incidence of sepsis in surgical patients?

Hemoperfusion as a Potential Treatment for Critically Ill COVID-19 Patients with Cytokine Storm

“…all ICU staff and physicians should be familiar with the concept of hemoperfusion in management of critically ill patients. So, hemoperfusion (early application) combined with appropriate antiviral therapies and supportive therapy may be considered as an adjunctive treatment for critically ill COVID-19 patients.”

Endotoxemia—menace, marker, or mistake?

How does endotoxin get into the bloodstream, and why is it so challenging to measure endotoxin in plasma?

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Alteco Medical AB • Höstbruksvägen 8 • SE-226 60 Lund • Sweden

T +46 46 32 86 00 • info@altecomed.com

© 2023 Alteco Medical AB

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