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  • Blood purification
    • Endotoxin removal
    • Take endotoxin out of the picture!
  • Applications
    • Indication and intended use
    • Turn the course of sepsis
    • Avoid post-operative complications
    • Endotoxin removal in COVID-19
  • Treatment
    • Early treatment start matters
    • How to use
    • Modes and set-up
    • Safety
    • Results
  • Case stories & studies
    • Case story: Wroclaw, Poland
    • Scientific report: Oulu University Hospital, Finland
    • Scientific report: Wroclaw, Poland
    • Scientific report: Caserta, Italy
    • List of studies & references
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  • Downloads
  • Blood purification
    • Endotoxin removal
    • Take endotoxin out of the picture!
  • Applications
    • Indication and intended use
    • Turn the course of sepsis
    • Avoid post-operative complications
    • Endotoxin removal in COVID-19
  • Treatment
    • Early treatment start matters
    • How to use
    • Modes and set-up
    • Safety
    • Results
  • Case stories & studies
    • Case story: Wroclaw, Poland
    • Scientific report: Oulu University Hospital, Finland
    • Scientific report: Wroclaw, Poland
    • Scientific report: Caserta, Italy
    • List of studies & references
  • Resources
    • IFU
    • Product FAQ
    • Webinars
    • Online training for distributors
    • Science database
  • News & events
  • Company
    • About us
    • Board
    • Team
    • Quality
    • Investor relations
    • Career
  • Contact
    • Contact us
    • Partners and distributors
    • New partnerships wanted
  • Downloads

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Alteco Medical AB
Höstbruksvägen 8
SE-226 60 Lund
Sweden

+46 46 32 86 00 
info@altecomed.com

Science database

Sepsis Pathogen Identification

What technologies are available for sepsis diagnosis and pathogen identification?

…”gram-negative bacteria produce lipopolysaccharides as endotoxins, which activate toll-like receptors on macrophages and other cells, eliciting the release of pro-inflammatory cytokines and chemokines. Constant stimulation of toll-like receptors leads to damage of vascular endothelial cells and causes blood-clotting abnormalities, eventually resulting in tissue injury, multiple organ dysfunction, and death.”

Formulation and screening of synthetic lipoproteins for binding and inhibition of endotoxin

Did you know that lipopolysaccharide (LPS) is the main molecular cause of sepsis?

Minimizing the release of proinflammatory and toxic bacterial products within the host: A promising approach to improve outcome in life-threatening infections

LPS (endotoxin) induces the release of a broad spectrum of inflammatory cytokines from human peripheral mononuclear blood cells.

Roles of the gut microbiota in severe SARS-CoV-2 infection

What role does LPS play in the gut-lung axis dysbiosis in COVID-19 patients? …”the direct invasion of the intestine by SARS-CoV-2 leads to increased intestinal permeability, allowing LPS produced by harmful bacteria to invade the body and stimulate the production of certain cytokines”…

Current status of bacterial translocation as a cause of surgical sepsis

Did you know that the gut is a source of endotoxin, and translocation of bacteria is associated with an increased incidence of sepsis in surgical patients?

Hemoperfusion as a Potential Treatment for Critically Ill COVID-19 Patients with Cytokine Storm

“…all ICU staff and physicians should be familiar with the concept of hemoperfusion in management of critically ill patients. So, hemoperfusion (early application) combined with appropriate antiviral therapies and supportive therapy may be considered as an adjunctive treatment for critically ill COVID-19 patients.”

Endotoxemia—menace, marker, or mistake?

How does endotoxin get into the bloodstream, and why is it so challenging to measure endotoxin in plasma?

Secondary infections modify the overall course of hospitalized COVID-19 patients: A retrospective study from a network of hospitals across North India

Secondary infections – most commonly gram-negative urinary tract infections and blood stream infections - complicate as much as 10% of COVID-19 patients in the hospital, increasing the need for oxygen, ICU care and almost doubling the length of stay.

Endotoxemia in Critically Ill Patients with COVID-19

Did you know that a significant proportion of critically ill COVID-19 patients have endotoxemia, independent of gram-negative bacteremia?

 

Endotoxemia and circulating bacteriome in severe COVID-19 patients

Endotoxin entering circulation following barrier dysfunction might contribute to the pathophysiology of COVID-19.

Figure 6

Lipopolysaccharides at the interface

Do you want to learn more about the structural and functional properties of LPS (lipopolysaccharides), also known as endotoxin? This study lets you dive into the details!

Prevalence and Outcomes of Previously Healthy Adults Among Patients Hospitalized with Community-Onset Sepsis

Did you know that younger, previously healthy patients may be at greater risk of dying from sepsis? To recognize and treat sepsis early in all patients is crucial.

 

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Alteco Medical AB • Höstbruksvägen 8 • SE-226 60 Lund • Sweden

T +46 46 32 86 00  •  info@altecomed.com

© 2022 Alteco Medical AB
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