Endotoxin removal
The Alteco LPS Adsorber contains discs made of porous polyethylene (PE) covered in a tailor-made peptide. The peptide binds to lipid A (the toxic part of endotoxin) with high affinity. By adsorbing harmful levels of endotoxin from the patient’s bloodstream, the Alteco LPS Adsorber can break the chain of immune system overreactions that can spiral into septic shock. This helps to stabilize the patient’s hemodynamic parameters in the acute situation.
Early treatment start
High levels of endotoxin activity are associated with organ failure and death. 1 For best treatment results, the Alteco LPS Adsorber should be used as early as possible. Hemoperfusion (HP) is the recommended treatment mode and allows treatment to start before acute kidney injury (AKI) escalates and the need for continuous renal replacement therapy (CRRT) arises.
Start treatment when the patient shows signs of imminent clinical deterioration, meaning:
- Urine production is decreasing (acute kidney failure approaching)
- Mean arterial pressure (MAP) ~ 65 mmHg
- >2 hours of vasopressor support and patient still unstable
Treatment results and clinical benefits
Post treatment, patients usually demonstrate a reduction in endotoxin, procalcitonin and lactate levels, a reduction or elimination of vasopressor support, stability and improvement in hemodynamic parameters as well as SOFA score.
Removing the threat
Our mission is to safely help stabilize patients through extracorporeal endotoxin elimination.
News
- John C. Marshall, et al; Diagnostic and Prognostic Implications of Endotoxemia in Critical Illness: Results of the MEDIC Study, The Journal of Infectious Diseases, Volume 190, Issue 3, 1 August 2004, Pages 527–534, https://doi.org/10.1086/422254
